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标题：Gut Health-Promoting Benefits of a Dietary Supplement of Vitamins with Inulin and Acacia Fibers in Rats
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作者：Malén Massot-Cladera ; Ignasi Azagra-Boronat ; Àngels Franch 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：8
页码：2196-2211
DOI：10.3390/nu12082196
出版社：MDPI Publishing
摘要：The study’s objective was to ascertain whether a nutritional multivitamin and mineral supplement enriched with two different dietary fibers influences microbiota composition, mineral absorption, and some immune and metabolic biomarkers in adult rats. Nine-week-old Wistar rats were randomly assigned into four groups: the reference group; the group receiving a daily supplement based on a food matrix with proteins, vitamins, and minerals; and two other groups receiving this supplement enriched with inulin (V I) or acacia (V A) fiber for four weeks. Microbiota composition was determined in cecal content and mineral content in fecal, blood, and femur samples. Intestinal IgA concentration, hematological, and biochemical variables were evaluated. Both V I and V A supplementations increased Firmicutes and Actinobacteria phyla, which were associated with a higher presence of Lactobacillus and Bifidobacterium spp. V A supplementation increased calcium, magnesium, phosphorus, and zinc concentrations in femur. V I supplementation increased the fecal IgA content and reduced plasma total cholesterol and uric acid concentration. Both fiber-enriched supplements tested herein seem to be beneficial to gut-health, although differently.
关键词：inulin fiber; acacia fiber; immune system; microbiota; mineral absorption; IgA inulin fiber ; acacia fiber ; immune system ; microbiota ; mineral absorption ; IgA