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标题：Stachys sieboldii Miq. Root Attenuates Weight Gain and Dyslipidemia in Rats on a High-Fat and High-Cholesterol Diet
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作者：Jennifer K. Lee ; Jae-Joon Lee ; Yeon-Kyoung Kim 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：7
页码：2063-2080
DOI：10.3390/nu12072063
出版社：MDPI Publishing
摘要：This study aimed at investigating the anti-obesity and anti-dyslipidemic effects of Stachys sieboldii Miq. root (SS) powder in rats following a high-fat and high-cholesterol (HFC) diet for 6 weeks. Thirty-two Sprague–Dawley rats were fed one of the following diets: a regular diet (RD), HFC, HFC supplemented with 3% SS (HFC 3SS) or HFC supplemented with 5% SS (HFC 5SS). Following an HFC diet increased body weight (BW) gain (p 3% SS; p < 0.001) and cholesterol (5% SS; p < 0.001) efflux levels were significantly elevated by the SS supplementation compared to those measured in the RD or HFC diet-fed groups. In addition, the hepatic lipid and cholesterol metabolism-related gene expressions were affected by SS consumption, as the hepatic anabolic gene expression (Acc; p < 0.001, Fas; p < 0.001 and G6pdh; p < 0.01) was significantly attenuated. The HFC 5SS diet-fed rats exhibited elevated hepatic Cyp7a1 (p < 0.001), Hmgcr (p < 0.001) and Ldlr (p < 0.001) mRNA expression levels compared to the HFC diet-fed rats. These results suggest that SS may possess anti-adipogenic and lipid-lowering effects by enhancing lipid and cholesterol efflux in mammals.
关键词：Stachys sieboldii Miq ; anti-obesity; cholesterol-lowering; high-fat and high-cholesterol (HFC) diet Stachys sieboldii Miq ; anti-obesity ; cholesterol-lowering ; high-fat and high-cholesterol (HFC) diet