文章基本信息

标题：Risk Factors Associated with Recurrent Clostridioides difficile Infection
本地全文：下载
作者：Nicoleta Negrut ; Simona Bungau ; Tapan Behl 等
期刊名称：Healthcare
电子版ISSN：2227-9032
出版年度：2020
卷号：8
期号：3
页码：352-363
DOI：10.3390/healthcare8030352
出版社：MDPI Publishing
摘要：Clostridioides difficile (CD) is responsible for nosocomial diarrhea syndrome with possible severe progression. Recurrence of the disease induces higher health system costs, as well as exposes patients to additional health risks. Patients with recurrence of this disease are difficult to identify, so the purpose of this study is to quantify various demographic, clinical, and treatment factors that could prevent further progression to recurrence of the disease. In the period 2018–2019, about 195 patients were diagnosed with more than one episode of CDI in the three months following the first episode. The recurrence rate for CDI was 53.84% (60.95% for one episode and 39.05% for multiple episodes). Most commonly afflicted were 60–69-year-old patients, or those with higher Charlson Comorbidity Index (CCI). Multiple analyses associated cardiovascular (odds ratios (OR) = 3.02, 95% confidence intervals (CI) = 1.23–7.39, p = 0.015), digestive (OR = 3.58, 95% CI = 1.01–12.63, p = 0.047), dementia (OR = 3.26, 95% CI = 1.26–8.41, p = 0.014), immunosuppressive (OR = 3.88, 95% CI = 1.34–11.21, p = 0.012) comorbidities with recurrences. Risk factor identification in the first episode of CDI could lead to the implementation of treatment strategies to improve the patients’ quality of life affected by this disease.
关键词：Clostridioides difficile ; recurrent disease; risk factors; antibiotic-associated diarrhea; ATLAS score; Charlson Comorbidity Index Clostridioides difficile ; recurrent disease ; risk factors ; antibiotic-associated diarrhea ; ATLAS score ; Charlson Comorbidity Index