文章基本信息

标题：Epigenome: A Biomarker or Screening Tool to Evaluate Health Impact of Cumulative Exposure to Chemical and Non-Chemical Stressors
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作者：Kenneth Olden ; Yu-Sheng Lin ; David Bussard 等
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2016
卷号：6
期号：2
页码：12-18
DOI：10.3390/bios6020012
出版社：MDPI Publishing
摘要：Current risk assessment practices and toxicity information are hard to utilize for assessing the health impact of combined or cumulative exposure to multiple chemical and non-chemical stressors encountered in the “real world” environment. Non-chemical stressors such as heat, radiation, noise, humidity, bacterial and viral agents, and social factors, like stress related to violence and socioeconomic position generally cannot be currently incorporated into the risk assessment paradigm. The Science and Decisions report released by the National Research Council (NRC) in 2009 emphasized the need to characterize the effects of multiple stressors, both chemical and non-chemical exposures. One impediment to developing information relating such non-chemical stressors to health effects and incorporating them into cumulative assessment has been the lack of analytical tools to easily and quantitatively monitor the cumulative exposure to combined effects of stressors over the life course.
关键词：chemical; cumulative; DNA methylation; environmental; epigenetics; epigenome; non-chemical; histone modification; stressors chemical ; cumulative ; DNA methylation ; environmental ; epigenetics ; epigenome ; non-chemical ; histone modification ; stressors