文章基本信息

标题：Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs
其他标题：Influencia de las nanopartículas poliméricas del propóleo rojo brasileño en las evaluaciones hematológicas, renales y hepáticas de perros
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作者：Mariana Rivelo Rodrigues de Melo ; Arnaldo Cesar Oliveira Gomes Lira Junior ; Karina Pessoa Oliveira 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2020
卷号：9
期号：11
页码：1-11
DOI：10.33448/rsd-v9i11.10531
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Recognized for various beneficial actions, propolis can be differentiated according to its origin. Red propolis, discovered in the northeast of Brazil, offers a strong antioxidant action. Nanoparticles are an innovative tool in the pharmaceutical field, as they help in efficient drug delivery. This study aimed to use red propolis nanoparticles in dogs and evaluate their action based on hematological and biochemical results. Eight healthy adult dogs (bodyweight, 6–27 kg) received 50 mg/animal of polymeric nanoparticles with 20% red propolis extract in a capsule, orally, once a day. Blood samples were collected weekly (five times), and hematologic, hepatic, and renal evaluations were performed. No significant changes were observed, except for alkaline phosphatase, which showed a significant reduction over time. This study in healthy adult dogs did not verify any hematologic, renal, or hepatic adverse effects of daily oral red propolis polymeric nanoparticles (capsules) administration. The results suggest a potential beneficial effect on the liver.
其他摘要：Recognized for various beneficial actions, propolis can be differentiated according to its origin. Red propolis, discovered in the northeast of Brazil, offers a strong antioxidant action. Nanoparticles are an innovative tool in the pharmaceutical field, as they help in efficient drug delivery. This study aimed to use red propolis nanoparticles in dogs and evaluate their action based on hematological and biochemical results. Eight healthy adult dogs (bodyweight, 6–27 kg) received 50 mg/animal of polymeric nanoparticles with 20% red propolis extract in a capsule, orally, once a day. Blood samples were collected weekly (five times), and hematologic, hepatic, and renal evaluations were performed. No significant changes were observed, except for alkaline phosphatase, which showed a significant reduction over time. This study in healthy adult dogs did not verify any hematologic, renal, or hepatic adverse effects of daily oral red propolis polymeric nanoparticles (capsules) administration. The results suggest a potential beneficial effect on the liver.
关键词：Canine; Adverse effects; Blood; Kidney; Liver.
其他关键词：Canine; Adverse effects; Blood; Kidney; Liver.