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标题：Symplocosins C–P: Fourteen Triterpene Saponins from the Leaves of Symplocos cochinchinensis var. philippinensis
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作者：Nobuhiro Ohyama ; Wen-Hu Cai ; Susumu Kawakami 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2020
卷号：68
期号：11
页码：1090-1099
DOI：10.1248/cpb.c20-00592
出版社：The Pharmaceutical Society of Japan
摘要：Extensive phytochemical work on the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Symplocos cochinchinensis var. philippinensis resulted in the isolation of 14 new triterpenene saponins, along with four known ones. Their structures were elucidated by comparison of NMR spectroscopic data with related compounds reported in the literature. Three oleanane-type saponins, symplocosins K, M, and P, possessed glucuronic acid as a sugar component, and their carboxyl groups appeared as methyl esters. These are probably formed during extraction and isolation procedures. Symplocosin K (9) showed moderate cytotoxicity toward A549 cells. In addition, all isolated compounds did not show α-glucosidase inhibitory activity.
关键词：Symplocos cochinchinensis var; philippinensis;Symlocaceae;oleanane;ursane;symplocosin;bioassay