文章基本信息

标题：Effect of the Molecularly Imprinted Polymer Component Ratio on Analytical Performance
本地全文：下载
作者：Kelvin Fernando Pratama ; Maretty Erwanta Roulina Manik ; Driyanti Rahayu 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2020
卷号：68
期号：11
页码：1013-1024
DOI：10.1248/cpb.c20-00551
出版社：The Pharmaceutical Society of Japan
摘要：Molecular imprinting technology is a new analytical method that is highly selective and specific for certain analytes in artificial receptor design. The renewal possibilities of this technology make it an ideal material for sundry application fields. Molecularly imprinted polymers (MIPs) are polymeric matrices that have molecules printed on their surfaces; these surfaces can chemically interact with molecules or follow the pattern of the available template cavities obtained using imprinting technology. A MIP is useful for separating and analysing complex samples, such as biological fluids and environmental samples, because it is a strong analytical recognition element that can mimick natural recognition entities like biological receptors and antibodies. The MIP components consist of the target template, functional monomer, crosslinker, polymerisation initiator, and porogen. The effectiveness and selectivity of a MIP are greatly influenced by variations in the components. This review will provide an overview of the effect of MIP component ratio on analytical performance to each target analyte; it will also provide a strategy to obtain the best MIP performance. For every MIP, each template : monomer : crosslinker ratio shows a distinct performance for a specific analyte. The effects of the template : monomer : crosslinker ratio on a MIP’s analytical performances—measured by the imprinting factor, sorbent binding capacity, and sorbent selectivity—are briefly outlined.
关键词：molecularly imprinted polymer component;imprinting factor;sorbent selectivity;molecularly imprinted polymer analytical performance;sorbent binding capacity