文章基本信息

标题：Macrophage Activation Syndrome as the First Impression of Kawasaki Disease; A Case Report
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作者：Ali Ahmadzadeh Amiri ; Payman Sadeghi ; Mahdieh Mousavi Torshizi 等
期刊名称：International Journal of Pediatrics
印刷版ISSN：2345-5047
电子版ISSN：2345-5055
出版年度：2019
卷号：7
期号：12
页码：10449-10454
DOI：10.22038/ijp.2019.41877.3529
出版社：Mashhad University of Medical Sciences
摘要：Introduction
Macrophage activation syndrome (MAS) is a rare and life-threatening complication of Kawasaki Disease (KD) that is usually diagnosed at the same time or after KD. We report a case of MAS as the initial manifestation of KD.
Case Report
A previously healthy 3-year old girl was admitted to the pediatric infectious diseases ward of Bahrami Children’s Hospital, Tehran, Iran. She had a 3-day history of fever and lymphadenopathy which persisted despite antibiotic therapy. Patient's general condition gradually worsened and she developed loss of consciousness. After being diagnosed with MAS based on laboratory findings, she developed mucocutaneous manifestations of KD. She responded to methylprednisolone pulse therapy, intravenous immunoglobulin and dipyridamole. The follow-up at 2 weeks and 2 months showed no abnormal findings.
Conclusion
MAS may manifest even before the diagnosis of KD is made. Early recognition of MAS associated with KD and prompt treatment with corticosteroids can improve the outcome.
关键词：Children; Iran; Macrophage activation syndrome; Kawasaki disease