文章基本信息

标题：Alteration of Platelet Indices in Young Children with Acute Pyelonephritis
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作者：Azar Nickavar ; Simin Sadeghi-Bojd
期刊名称：International Journal of Pediatrics
印刷版ISSN：2345-5047
电子版ISSN：2345-5055
出版年度：2020
卷号：8
期号：8
页码：11743-11749
DOI：10.22038/ijp.2020.47464.3849
出版社：Mashhad University of Medical Sciences
摘要：Background
Platelets have an important contribution in pathogenesis of different infectious and inflammatory disorders. This study was performed to identify the diagnostic value of platelet count (PLT), and platelet indices in children with acute pyelonephritis (APN).
Materials and Methods
In a cross sectional case control study, a total of 91 children with APN and 90 healthy control children were investigated during 2018-2019. About 3 ml EDTA blood was drawn before antibiotic treatment and investigated for white blood count (WBC), Hemoglobin level, mean corpuscular volume (MCV), platelet counts, and platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (PLCR) in two groups. Then, the results were compared in two groups.
Results
Mean age at diagnosis of patients was 34.57±30.96 months. Children with APN had significantly higher PLT, along with lower MPV, PDW and PLCR, compared to the normal healthy group. Using the best cutoff points, PLT>452000, and MPV≤7.7 had the highest sensitivity (96.67%) and specificity (92.22%) for diagnosis of APN, respectively. Based on AUC, PLT and platelet indices were accurate diagnostic markers of APN.
Conclusion
Based on the results, PLT and platelet indices were fast and additional tests for diagnosis of children with acute febrile urinary tract infection.
关键词：Acute pyelonephritis; Children; MPV; platelet index; Urinary tract infection