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标题：Performance demonstration of a hybrid Compton camera with an active pinhole for wide-band X-ray and gamma-ray imaging
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作者：Akihisa Omata ; Jun Kataoka ; Kazuya Fujieda 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2020
卷号：10
期号：1
DOI：10.1038/s41598-020-71019-5
出版社：Springer Nature
摘要：X-ray and gamma-ray imaging are technologies with several applications in nuclear medicine, homeland security, and high-energy astrophysics. However, it is generally difficult to realize simultaneous wide-band imaging ranging from a few tens of keV to MeV because different interactions between photons and the detector material occur, depending on the photon energies. For instance, photoabsorption occurs below 100 keV, whereas Compton scattering dominates above a few hundreds of keV. Moreover, radioactive sources generally emit both X-ray and gamma-ray photons. In this study, we develop a “hybrid” Compton camera that can simultaneously achieve X-ray and gamma-ray imaging by combining features of “Compton” and “pinhole” cameras in a single detector system. Similar to conventional Compton cameras, the detector consists of two layers of scintillator arrays with the forward layer acting as a scatterer for high-energy photons (> 200 keV) and an active pinhole for low-energy photons (< 200 keV). The experimental results on the performance of the hybrid camera were consistent with those from the Geant4 simulation. We simultaneously imaged $$^{241}$$ Am (60 keV) and $$^{137}$$ Cs (662 keV) in the same field of view, achieving an angular resolution of 10 $$^ rc $$ (FWHM) for both sources. In addition, imaging of $$^{211}$$ At was conducted for the application in future nuclear medicine, particularly radionuclide therapy. The initial demonstrative images of the $$^{211}$$ At phantom were reconstructed using the pinhole mode (using 79 keV) and Compton mode (using 570 keV), exhibiting significant similarities in source-position localization. We also verified that a mouse injected with 1 MBq of $$^{211}$$ At can be imaged via pinhole-mode measurement in an hour.