Politics is one of the hottest and most commonly mentioned and viewed topics on social media networks nowadays. Microblogging platforms like Twitter and Weibo are widely used by many politicians who have a huge number of followers and supporters on those platforms. It is essential to study the supporters’ network of political leaders because it can help in decision making when predicting their political futures. This study focuses on the supporters’ network of three famous political leaders of Pakistan, namely, Imran Khan (IK), Maryam Nawaz Sharif (MNS), and Bilawal Bhutto Zardari (BBZ). This is done using social network analysis and semantic analysis. The proposed method (1) detects and removes fake supporter(s), (2) mines communities in the politicians’ social network(s), (3) investigates the supporters’ reply network for conversations between supporters about each leader, and, finally, (4) analyses the retweet network for information diffusion of each political leader. Furthermore, sentiment analysis of the supporters of politicians is done using machine learning techniques, which ultimately predicted and revealed the strongest supporter network(s) among the three political leaders. Analysis of this data reveals that as of October 2017 (1) IK was the most renowned of the three politicians and had the strongest supporter’s community while using Twitter in a very controlled manner, (2) BBZ had the weakest supporters’ network on Twitter, and (3) the supporters of the political leaders in Pakistan are flexible on Twitter, communicating with each other, and that any group of supporters has a low level of isolation.