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标题：Reply to Zhao et al.: NOMO1 is a potential target gene of MRTFB
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作者：Teresa A. Marian ; Zhubo Wei
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：14
页码：7570-7571
DOI：10.1073/pnas.2000772117
出版社：The National Academy of Sciences of the United States of America
摘要：Our recent article reports the important suppressing role of MRTFB (myocardin-related transcription factor B) in colorectal cancer (CRC) and reveals several target genes of MRTFB’s transcription activity, including SPDL1 and MCAM (1). We initiated the study because Mrtfb was identified as a candidate tumor suppressor gene in a forward genetic screen using the Sleeping Beauty (SB) transposon system (2). We do not investigate whether single-nucleotide polymorphism (SNP) contributes to MRTFB’s function in CRC, as the SB transposon system does not generate point mutations (3). Zhao et al. (4) propose a new target gene, NOMO1 … [↵][1]1To whom correspondence may be addressed. Email: zwei{at}houstonmethodist.org. [1]: #xref-corresp-1-1