文章基本信息

标题：Iriomoteolides-14a and 14b, New Cytotoxic 15-Membered Macrolides from Marine Dinoflagellate Amphidinium Species
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作者：Masashi Tsuda ; Ryui Makihara ; Masayuki Tsuda 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2020
卷号：68
期号：9
页码：864-867
DOI：10.1248/cpb.c20-00329
出版社：The Pharmaceutical Society of Japan
摘要：Two new macrolides, iriomoteolides-14a ( 1 ) and 14b ( 2 ) have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09057).Compounds 1 and 2 are 15-membered macrolides, which are structural analogs of amphidinolides O ( 3 ) and P ( 4 ).The structures of 1 and 2 were assigned on the basis of detailed NMR analyses and chemical conversion studies.Compounds 1 and 2 showed moderate cytotoxic activity against human cervix adenocarcinoma HeLa cells.
关键词：macrolide;dinoflagellate;Amphidinium