文章基本信息

标题：A Brief Overview of Restricted Mean Survival Time Estimators and Associated Variances
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作者：Szilárd Nemes ; Erik Bülow ; Andreas Gustavsson 等
期刊名称：Stats
电子版ISSN：2571-905X
出版年度：2020
卷号：3
期号：2
页码：107-119
DOI：10.3390/stats3020010
出版社：MDPI AG
摘要：Restricted Mean Survival Time ( R M S T ) experiences a renaissance and is advocated as a model-free, easy to interpret alternative to proportional hazards regression and hazard rates with implication in causal inference. Estimation of R M S T and associated variance is mainly done by numerical integration of Kaplan–Meier curves. In this paper we briefly review the two main alternatives to the Kaplan–Meier method; analysis based on pseudo-observations, and the flexible parametric survival method. Using computer simulations, we assess the efficacy of the three methods compared to a fully parametric approach where the distribution of survival times is known. Thereafter, the three methods are directly compared without any distributional assumption for the survival data. Generally, flexible parametric survival methods outperform both competitors, however the differences are small.
关键词：RMST; censoring; variance estimator; efficacy; Kaplan–Meier; flexible-survival methods; pseudo-observation