文章基本信息

标题：Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)
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作者：Edgar Garcia-Rill ; Brennon Luster ; Stasia D’Onofrio 等
期刊名称：Sleep Science
印刷版ISSN：1984-0659
电子版ISSN：1984-0063
出版年度：2015
卷号：8
期号：3
页码：153-161
DOI：10.1016/j.slsci.2015.09.001
出版社：Brazilian Association of Sleep and Latin American Federation of Sleep Societies
摘要：This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.
关键词：Basal forebrain;Calcium channels;Gamma band activity;Lateral hypothalamus;Orexin;Tuberomammillary