文章基本信息

标题：Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
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作者：Francisco J. Urbano ; Verónica Bisagno ; Betina González 等
期刊名称：Sleep Science
印刷版ISSN：1984-0659
电子版ISSN：1984-0063
出版年度：2015
卷号：8
期号：3
页码：162-168
DOI：10.1016/j.slsci.2015.09.004
出版社：Brazilian Association of Sleep and Latin American Federation of Sleep Societies
摘要：This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal’s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration.
关键词：Amphetamine;Cocaine;Dopamine;Nicotine;P/Q-type calcium channels;T-type calcium channels