文章基本信息

标题：Pedunculopontine arousal system physiology—Implications for schizophrenia
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作者：Edgar Garcia-Rill ; Stasia D’Onofrio ; Susan Mahaffey 等
期刊名称：Sleep Science
印刷版ISSN：1984-0659
电子版ISSN：1984-0063
出版年度：2015
卷号：8
期号：2
页码：82-91
DOI：10.1016/j.slsci.2015.04.003
出版社：Brazilian Association of Sleep and Latin American Federation of Sleep Societies
摘要：Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased {REM} sleep drive. Other arousal-related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of disturbances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia.
关键词：Calcium channels;Gamma band activity;Neuronal calcium sensor protein;P50 potential