文章基本信息

标题：Pedunculopontine arousal system physiology – Implications for insomnia
本地全文：下载
作者：Edgar Garcia-Rill ; Brennon Luster ; Susan Mahaffey 等
期刊名称：Sleep Science
印刷版ISSN：1984-0659
电子版ISSN：1984-0063
出版年度：2015
卷号：8
期号：2
页码：92-99
DOI：10.1016/j.slsci.2015.06.002
出版社：Brazilian Association of Sleep and Latin American Federation of Sleep Societies
摘要：We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and {REM} sleep is controlled by two different intracellular pathways and channel types in {PPN} cells. We found three different {PPN} cell types that have one or both channels and may be active during waking only, {REM} sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.
关键词：CaMKII; calcium/calmodulin-dependent protein kinase;Calcium channels;EEG; electroencephalogram;Gamma band activity;KA; kainic acid;N-type calcium channel;NCS-1; neuronal calcium sensor protein 1;NMDA; n methyl d aspartic acid;Neuronal calcium sensor protein;P/Q-type calcium channel;PGO; ponto-geniculo-occipital;PPN; pedunculopontine nucleus;RAS; reticular activating system;REM; rapid eye movement;SWS; slow wave sleep;cAMP; cyclic adenosine monophosphate;ω-Aga; ω-agatoxin-IVA;ω-CgTx; ω-conotoxin-GVIA