文章基本信息

标题：Low Dose Radiation-Induced Adaptive Survival Response in Mouse Spleen T-lymphocytes in vivo.
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作者：NAOKI YOSHIDA ; HAJIME IMADA ; NAOKI KUNUGITA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1993
卷号：34
期号：4
页码：269-276
DOI：10.1269/jrr.34.269
摘要：Induction of an adaptive survival response in 1360171 mice exposed to whole-body irradiation by low doses of X-rays (priming exposure) then to high doses of X-rays (challenge exposure) was examined. The adaptive survival response was determined by comparing the cloning efficiency of low dose-irradiated spleen T-lymphocytes to that of unprimed controls. Maximal expression of the adaptive survival response induced by exposure to low doses of X-rays occurred 7 hours after the priming exposure. The optimal low dose range for the induction of the adaptive survival response was 0.05-0.1 Gy. Thus, low dose X-irradiation induces the adaptive response in spleen T-lymphocytes of B6C3F1 mice as assessed by survival. The duration of this response is short, and there is an optimal low dose range. The Dq value for the primed cells was somewhat larger than that for the unprimed ones. Low dose exposure may enhance the capacity of spleen cells for repair during priming.
关键词：Adaptive response;Cell survival;Low dose radiation;T-lymphocyte;Mice