文章基本信息

标题：Radiation Induced Dynamic Mutations and Transgenerational Effects
其他标题：Radiation Induced Dynamic Mutations and Transgenerational Effects
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作者：Ohtsura NIWA
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2006
卷号：47
期号：SupplementB
页码：25-30
DOI：10.1269/jrr.47.B25
摘要：Many studies have confirmed that radiation can induce genomic instability in whole body systems. Although the molecular mechanisms underlying induced genomic instability are not known at present, this interesting phenomenon could be the manifestation of a cellular fail-safe system in which fidelity of repair and replication is down-regulated to tolerate DNA damage. Two features of genomic instability namely, delayed mutation and untargeted mutation, require two mechanisms of `damage memory' and `damage sensing, signal transduction and execution' to induce mutations at a non damaged-site. In this report, the phenomenon of transgenerational genomic instability and possible mechanisms are discussed using mouse data collected in our laboratory as the main bases.
关键词：Dynamic mutation; Minisatellite; Genomic instability; p53 response