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标题：Vitamin E and L-carnitine, Separately or in Combination, in The Prevention of Radiation-induced Oral Mucositis and Myelosuppression: a Controlled Study in A Rat Model
其他标题：Vitamin E and L-carnitine, Separately or in Combination, in The Prevention of Radiation-induced Oral Mucositis and Myelosuppression: a Controlled Study in A Rat Model
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作者：Harun ÜÇÜNCÜ ; Mustafa Vecdi ERTEKIN ; Özgür YÖRÜK 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2006
卷号：47
期号：1
页码：91-102
DOI：10.1269/jrr.47.91
摘要：The aim of this study was to determine the effects of vitamin E (VE) and L-carnitine (LC) supplementation, separately or in combination, on radiation-induced oral mucositis and myelosuppression. Group 1 received no treatment (control). Group 2 received 15 Gray of 60 Co gamma irradiation as a single dose to total cranium (IR). Group 3, 4, and 5 received irradiation plus 40 mg/kg/day VE (IR VE) or 200 mg/kg/day LC (IR LC) or in combination (IR VE LC) respectively. Clinically and histopathologically, assessments of mucosal reactions were performed by two independent experts in Radiation Oncology and Pathology, respectively. Hematologic analyses and antioxidant enzyme evaluations were also performed. Irradiation significantly increased oral mucositis, and decreased thrombocyte and White Blood Cell counts. A significant increase in malondialdehyde (MDA) levels and decrease in superoxide dismutase (SOD) and catalase (CAT) activities in plasma were found in the IR group. VE and LC administration, separately, plus irradiation significantly delayed the starting day, and reduced the severity of, oral mucositis. This administration also reduced a fall in the numbers of thrombocyte and WBC caused by irradiation, and decreased the MDA level, and increased the activity of SOD and CAT enzymes in the plasma. VE and LC, in combination, plus irradiation did not provide a superior radioprotection against radiation-induced toxicities.
关键词：Gamma irradiation; Oral mucosa; Mucositis; Vitamin E; L-carnitine