文章基本信息

标题：Differences in heavy-ion-induced DNA double-strand breaks in a mouse DNA repair-deficient mutant cell line (SL3-147) before and after chromatin proteolysis.
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作者：MASAHIRO MURAKAMI ; KIYOMI EGUCHI-KASAI ; KOKI SATO 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1995
卷号：36
期号：4
页码：258-264
DOI：10.1269/jrr.36.258
摘要：DNA double-strand breaks induced by X- or neon beam-irradiation in a DNA double-strand break-repair-deficient mutant cell line (SL3-147) were examined. The increase in the number of DNA double-strand breaks was dose depend after irradiation with X-rays and neon beams and was enhanced by chromatin-proteolysis treatment before irradiation. These results suggest that the induction of DNA double-strand breaks by ionizing radiation, including heavy-ions, is influenced by the chromatin structure.
关键词：DNA double-strand break;Heavy-ion;Ne beam;DNA repair;mouse mutant cell line.