文章基本信息

标题：Modification of the Radiosensitivity of Human Cells to which Simian Virus 40 T-antigen was transfected.
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作者：NOBUYUKI YAMAGISHI ; JUNJI MIYAKOSHI ; SHUJI OHTSU 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1995
卷号：36
期号：4
页码：239-247
DOI：10.1269/jrr.36.239
摘要：Effects of the introduction of the Simian virus 40 T-antigen (SV40 T-Ag) gene to cultured human cells were examined in relation to radiosensitivity. Two relatively radioresistant tumor cell lines (T98 and G361) became significantly radiosensitive after the introduction of SV40 T-Ag, whereas radiosensitive tumor cell lines did not show a change in radiosensitivity. In contrast, a human fibroblast cell line became radioresistant after SV40 T-Ag introduction. T98 cells which have a mutation at codon 237 in the p53 gene were unable to form a complex between p53 protein and SV40 T-Ag, whereas G361, which became radiosensitive by a SV40 T-Ag introduction, formed the complex. This indicates that the status of p53 is independent of the change in radiosensitivity in the cell lines studied.
关键词：SV40 T-antigen;Radiosensitivity;X-ray irradiation;p53