文章基本信息

标题：Rapid Decrease in Brain Enkephalin Content after Low-dose Whole-body X-Irradiation of the Rat.
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作者：YUKIHISA MIYACHI ; NORIO OGAWA ; AKITANE MORI 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1992
卷号：33
期号：1
页码：11-15
DOI：10.1269/jrr.33.11
摘要：Methionine-enkephalin (ME) contents in the hypothalamus and other rat brain structures were measured immediately after 10 or 20 cGy whole-body X-irradiation. The ME contents of homogenates of the striatum, hypothalamus, midbrain thalamus, hindbrain and pituitary were assayed radioimmunologically with 125 I. The contents of all the structures, except the pituitary, decreased significantly after 20 cGy irradiation. The reduction in the hypothalamus was transient, ME content gradually recovering with time. These results suggest that the central nervous system of mammals is one of the most radiosensitive organs as judged by changes in stress-induced mediators such as ME.
关键词：enkephalin; low-dose; neurotransmitter; central nervous system; radiosensitivity