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标题：Augmentation of NO Production and Cytolytic Activity of M.PHI. Obtained from Mice Irradiated with a Low Dose of .GAMMA.-Rays.
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作者：YUKO IBUKI ; RENSUKE GOTO
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1995
卷号：36
期号：3
页码：209-220
DOI：10.1269/jrr.36.209
摘要：The activation of macrophages (Mφ) by low-dose irradiation (4cGy) was examined. The irradiated Mφ were obtained from mice exposed to a low dose of γ-rays. The addition of excess irradiated Mφ suppressed more the concanavalin A-induced proliferation of splenocytes than that of unirradiated Mφ. This was attributed to large nitric oxide (NO) production from irradiated Mφ. In addition, low-dose irradiation augmented NO production and glucose consumption in Mφ treated with interferon-γ alone or interferon-γ/ lipopolysaccharide. Furthermore, low-dose-irradiated Mφ showed a higher cytolytic activity against P-815 mastocytoma cells than unirradiated Mφ, indicating that the NO production was involved in the activity. On the other hand, the Mφ irradiated with a low dose in vitro did not enhance the NO production. These findings suggest that whole-body irradiation with a low dose of γ-rays activates Mφ indirectly and consequently enhances NO production from Mφ, by which the self-defense systems such as the tumoricidal activity will be augmented.
关键词：macrophage; low-dose irradiation; nitric oxide; tumoricidal activity; Con A-induced proliferation