文章基本信息

标题：Enhancement of Concanavalin A-induced Proliferation of Spleno-Lymphocytes by Low-dose-irradiated Macrophages.
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作者：YUKO IBUKI ; RENSUKE GOTO
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1994
卷号：35
期号：2
页码：83-91
DOI：10.1269/jrr.35.83
摘要：The effect of whole-body irradiation with low doses of γ-rays was investigated for the Con A-induced proliferation of splenocytes. Proliferation was enhanced by 0.02Gy irradiation, but was inhibited by 0.2Gy. The enhanced proliferation produced by low-dose irradiation also was studied using co-cultures of splenolymphocytes and peritoneal macrophages (Mφs) instead of spleno-Mφs. The proliferative response of spleno-lymphocytes was not affected by low doses of γ-ray irradiation; whereas, the responses of unirradiated spleno-lymphocytes cultured with the peritoneal Mφs that had been irradiated at 0.02 and 0.04Gy respectively were about 120 and 145% of the control. Proliferative enhancement was found when peritoneal Mφs collected 4h after whole-body irradiation were used, but not with those collected at 1 and 12h. No enhancement took place when in vitro irradiation was used. These results suggest that the enhancement in Con A-induced proliferation of splenocytes by low-dose irradiation was caused not by the activation of spleno-lymphocytes, but by activation of spleno-Mφs, and that the Mφs were activated indirectly.
关键词：γ-ray; low-dose irradiation; Con A; splenocyte; macrophage