文章基本信息

标题：Glycine Betaine, a Beer Component, Protects Radiation-induced Injury
其他标题：Glycine Betaine, a Beer Component, Protects Radiation-induced Injury
本地全文：下载
作者：Manami MONOBE ; Akiko UZAWA ; Makiko HINO 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2005
卷号：46
期号：1
页码：117-121
DOI：10.1269/jrr.46.117
摘要：Human whole-blood was exposed to 137 Cs γ-rays or 50 keV/μm carbon ions in the presence or absence of glycine betaine, a beer component in vitro . The dicentrics of chromosome aberrations in human lymphocytes were significantly ( p < 0.05) reduced by glycine betaine after irradiation with 4 Gy of either γ-rays or carbon ions. The maximum protection by glycine betaine for γ-rays or carbon ions was 37% and 20%, respectively. C3H/He female mice, aged 14 weeks, received an i.p. injection of glycine betaine 15 min before whole-body irradiation with γ-rays or 50 keV/μm carbon ions. Glycine betaine significantly ( p < 0.05) increased the percent survival of irradiated mice with either γ-rays or carbon ions. In conclusion, glycine betaine is a potent protector against damages caused by low- and high-LET radiation.
关键词：Glycine betaine; Radioprotection; Chromosome aberration; γ-rays; Heavy ions