文章基本信息

标题：Influence of Seed Extract of Syzygium Cumini (Jamun) on Mice Exposed to Different Doses of γ-radiation
其他标题：Influence of Seed Extract of Syzygium Cumini (Jamun) on Mice Exposed to Different Doses of γ-radiation
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作者：Ganesh Chandra JAGETIA ; Manjeshwar Shrinath BALIGA ; Ponemone VENKATESH 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2005
卷号：46
期号：1
页码：59-65
DOI：10.1269/jrr.46.59
摘要：The radioprotective activity of the hydroalcoholic extract of jamun seeds (SCE) was studied in mice exposed to different doses of gamma radiation. The mice were injected with 0, 5, 10, 20, 40, 60, 80, 100, 120, 140 or 160 mg/kg body weight of SCE, before exposure to 10 Gy of gamma radiation, to select the optimum dose of radiation protection. The 80 mg/kg SCE was found to offer highest protection, therefore, further studies were carried out using this dose. The drug was more effective when administered through the intraperitoneal route at equimolar doses than the oral route. Since higher survival was observed for the i.p. route (50%), than the oral route (29.2%), all other studies were carried out by injecting SCE intraperitoneally. The mice treated with 80 mg/kg body weight SCE intraperitoneally before exposure to 6, 7, 8, 9, 10 and 11 Gy of gamma radiation showed reduction in the symptoms of radiation sickness and mortality at all exposure doses and caused a significant increase in the animal survival when compared with the concurrent double distilled water (DDW) irradiation group. The SCE treatment protected mice against the gastrointestinal as well as bone marrow deaths and the DRF was found to be 1.24.
关键词：Syzygium cumini ; Mice; survival; Gamma radiation; Radioprotection