文章基本信息

标题：Cytogenetic Radiosensitivity of G0-Lymphocytes of Breast and Esophageal Cancer Patients as Determined by Micronucleus Assay
其他标题：Cytogenetic Radiosensitivity of G0-Lymphocytes of Breast and Esophageal Cancer Patients as Determined by Micronucleus Assay
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作者：Hossein MOZDARANI ; Zahra MANSOURI ; S. Abolghasem HAERI 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2005
卷号：46
期号：1
页码：111-116
DOI：10.1269/jrr.46.111
摘要：Enhanced chromosomal radiosensitivity is a feature of many cancer predisposition conditions, indicative of the important role of chromosomal alterations in carcinogenesis. In this study the cytokinesis-blocked micronucleous assay was used to compare the radiosensitivity of blood lymphocytes obtained from Iranian breast or esophageal cancer patients (n = 50, n = 16; respectively) with that of control individuals (n = 40). For each sample, one thousand binucleate lymphocytes were analyzed before and after in vitro exposure to 3 Gy of γ rays. The radiation-induced frequency of micronucleus was significantly higher in the breast cancer group (261/1,000 binucleated cells) than in esophageal cancer group (241/1,000 binucleated cells, P < 0.01) or in the control group (240/1,000 binucleated cells, P < 0.01). The results indicate that breast cancer patients are more radiosensitive compared to normal healthy individuals or esophageal cancer patients. Increased radiosensitivity could be due to defects in DNA repair genes involved in breast cancer formation. Since patients with esophageal cancer did not show elevated radiosensitivity, it is assumed that the contribution of radiosensitivity-related genes to the development of esophageal cancer may be smaller than the contribution of those genes to breast cancer.
关键词：Radiosensitivity; Human lymphocytes; Breast cancer; Esophageal cancer; Micronuclei