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标题：High Incidence of Malignant Lung Carcinomas in Rats after Inhalation of 239PuO2 Aerosol.
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作者：YOICHI OGHISO ; YUJI YAMADA ; NOBUHITO ISHIGURE 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1994
卷号：35
期号：4
页码：222-235
DOI：10.1269/jrr.35.222
摘要：Female Wistar strain rats were exposed to a single inhalation of a submicron-size aerosol of high-fired 239 PuO 2 to investigate pulmonary carcinogenesis during lifespan periods. The absorbed lung doses of the exposed anmals ranged from 0.6 to 12 Gy and were well correlated with the initial lung deposition (ILD) of 0.1 to 2.3 kBq. Survival and induction of primary lung tumors in 116 exposed rats were compared with those in 56 untreated control rats in respect to lung doses received. Mean survival time was greatly reduced, and the cumulative incidence of total lung tumors was markedly increased to 90-100% in rats that received more than 4 Gy, whereas of the controls only one animal (1.8%) died of primary lung tumors. Primary but benign adenomas were present in exposed animals given 1.0 Gy or less, and the incidence of adenomas was 22-25% at 4-5 Gy, but decreased sharply to 3-5% at 6-8 Gy. In contrast, no malignant carcinomas, including adenocarcinomas, adenosquamous carcinomas and squamous cell carcinomas, developed at a dose of less than 1.0 Gy, whereas they were present in 75% or more of the rats given 4-10 Gy, but only in 55% at 12 Gy. Although there were no clear differences in the dose and time required for induction among the carcinoma types, all tended to develope in earlier periods after inhalation than adenomas. Despite the limited number of exposed animals that received lower doses, results suggest that malignant lung carcinomas are highly and early induced and have a different dose-effect relationship than benign adenomas at doses of more than 1 Gy after inhalation exposure to 239 PuO 2 .
关键词：Inhalation;carcinogenesis;239PuO2;aerosol;lung dose