文章基本信息

标题：Effect of multiple-dose irradiation on repair capacity in plateau phase C3H 10T1/2 cells.
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作者：NOBUO KUBOTA ; TADASHI IKEGAMI ; TAE IWASAWA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1990
卷号：31
期号：3
页码：235-245
DOI：10.1269/jrr.31.235
摘要：Using plateau phase C3H 10T½ cells, we studied the effect of multiple-dose irradiation on the repair capacity of cells after further irradiation. Cells were irradiated with repeated doses of 2.5 Gy delivered two fractions per day at 6 to 7 hours interval. The cell survival after exposure to 1 to 9 fractions was lower above 5 fractions as compared to that predicted by calculating from single dose survival curve by assuming that cells retain their capacity to repair radiation damage after each fraction. Repair kinetics experiments showed that cells were less able to repair potentially lethal damage after test dose following multiple dose irradiations. There was, however, no difference in the ability to repair sublethal damage and potentially lethal damage sensitive to anisotonic treatment in preirradiated and untreated cells. Thus, it would appear that an enhancement of the lethal expression of potentially lethal damage of three types of damage may, at least in part, contribute to the difference between the cell survival curve after multiple fractions and that predicted by calculation.
关键词：C3H 10T½; Multiple fraction; SLD; PLD; Repair