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标题：Radioprotective Effects of Hawthorn Fruit Extract Against Gamma Irradiation in Mouse Bone Marrow Cells
其他标题：Radioprotective Effects of Hawthorn Fruit Extract Against Gamma Irradiation in Mouse Bone Marrow Cells
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作者：Seyed Jalal HOSSEINIMEHR ; Mohammad AZADBAKHT ; Seyedeh Maryam MOUSAVI 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2007
卷号：48
期号：1
页码：63-68
DOI：10.1269/jrr.06032
摘要：The radioprotective effect of hawthorn (Crataegus microphylla) fruit extract against genotoxicity induced by gamma irradiation has been investigated in mouse bone marrow cells. A single intraperitoneal (ip) administration of hawthorn extract at doses of 25, 50, 100 and 200 mg/kg 1h prior to gamma irradiation (2 Gy) reduced the frequencies of micronucleated polychromatic erythrocytes (MnPCEs). All four doses of hawthorn extract significantly reduced the frequencies of MnPCEs and increased the PCE/PCE NCE ratio (polychromatic erythrocyte/ polychromatic erythrocyte normochromatic erythrocyte) in mice bone marrow compared with the non drug-treated irradiated control (p < 0.02-0.00001). The maximum reduction in MnPCEs was observed in mice treated with extract at a dose of 200 mg/kg. Administration of amifostine at dose 100 mg/kg and hawthorn at dose 200 mg/kg reduced the frequency of MnPCE almost 4.8 and 5.7 fold; respectively, after being exposed to 2 Gy of gamma rays, compare with the irradiated control group. Crataegus extract exhibited concentration-dependent activity on 1,1-diphenyl 2-picrylhydrazyl free radical showing that Crataegus contained high amounts of phenolic compounds and the HPLC analysis determined that it contained chlorogenic acid, epicatechin and hyperoside. It appeared that hawthorn extract with antioxidant activity reduced the genotoxicity induced by gamma irradiation in bone marrow cells.
关键词：Crataegus microphylla; Radioprotective; Micronucleus; Irradiation; Hawthorn