文章基本信息

标题：Heavy-Ion Microbeam System at JAEA-Takasaki for Microbeam Biology
其他标题：Heavy-Ion Microbeam System at JAEA-Takasaki for Microbeam Biology
本地全文：下载
作者：Tomoo FUNAYAMA ; Seiichi WADA ; Yuichiro YOKOTA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2008
卷号：49
期号：1
页码：71-82
DOI：10.1269/jrr.07085
摘要：Research concerning cellular responses to low dose irradiation, radiation-induced bystander effects, and the biological track structure of charged particles has recently received particular attention in the field of radiation biology. Target irradiation employing a microbeam represents a useful means of advancing this research by obviating some of the disadvantages associated with the conventional irradiation strategies. The heavy-ion microbeam system at JAEA-Takasaki, which was planned in 1987 and started in the early 1990's, can provide target irradiation of heavy charged particles to biological material at atmospheric pressure using a minimum beam size 5 μm in diameter. A variety of biological material has been irradiated using this microbeam system including cultured mammalian and higher plant cells, isolated fibers of mouse skeletal muscle, silkworm ( Bombyx mori ) embryos and larvae, Arabidopsis thaliana roots, and the nematode Caenorhabditis elegans. The system can be applied to the investigation of mechanisms within biological organisms not only in the context of radiation biology, but also in the fields of general biology such as physiology, developmental biology and neurobiology, and should help to establish and contribute to the field of "microbeam biology".
关键词：Heavy-ion microbeam; Target irradiation; Bystander effect; Biologically effective track; Low dose effect