文章基本信息

标题：Ectopic Neurons in the Hippocampus may be a Cause of Learning Disability after Prenatal Exposure to X-rays in Rats
其他标题：Ectopic Neurons in the Hippocampus may be a Cause of Learning Disability after Prenatal Exposure to X-rays in Rats
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作者：Nobuhiko TAKAI ; Xue-Zhi SUN ; Koichi ANDO 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2004
卷号：45
期号：4
页码：563-569
DOI：10.1269/jrr.45.563
摘要：The relationship between an impairment of spatial navigation and an incidence of ectopic neurons in the dorsal hippocampus was investigated in adult rats that were prenatally exposed to X-ray irradiation. Adult rats which had received 1.5 Gy X-rays at embryonic day 15 (E15) showed significant learning disability in the water-maze task. According to the mean value of the swimming time, we categorized the irradiated adult rats into the following three groups: slightly damaged group, mildly damaged group and severely damaged group. No significant difference in the brain weight was found between the three categorized groups. Ectopic neurons appearing at abnormal places were prominently observed in the dorsal hippocampus of the severely damaged group with a remarkable learning disturbance, while no ectopia in the hippocampus was observed in the slightly damaged group. This may suggest that the cognitive dysfunction induced by prenatal exposure to X-ray irradiation may be, at least in part, attributable to ectopic neurons of the hippocampus.
关键词：Prenatal X-irradiation;Hippocampus;Memory;Heterotopic gray matter