文章基本信息

标题：Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues.
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作者：RIICHI TAWA ; YUTAKA KIMURA ; JUN-ICHIRO KOMURA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1998
卷号：39
期号：4
页码：271-278
DOI：10.1269/jrr.39.271
摘要：Effects of ionizing radiation on the level of genomic DNA methylation in liver, brain and spleen of mouse as well as in two kinds of cultured cells were examined by high-performance liquid chromatography. Ten Gy of whole body X-radiation reduced the 5-methyldeoxycytidine contents by about 40% within 8 hours after irradiation in liver. Similar effects were observed at 4 or 7 Gy of X-ray irradiation. However, no such change was detected in brain, spleen and cultured cells. The data indicate that radiation-induced alteration in genomic DNA methylation is not ubiquitous among different tissues and cells.
关键词：X-rays;Tissues;HPLC;5-methyldeoxycytidine;Demethylation