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标题：Effects of Dose Rate and Energy Level on Fission Neutron(252Cf) Tumorigenesis in B6C3F1 Mice.
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作者：HIROMITSU WATANABE ; TARO OKAMOTO ; KAZUMASA YAMADA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1993
卷号：34
期号：3
页码：235-239
DOI：10.1269/jrr.34.235
摘要：The effects of the dose rate and the energy of fission neutrons using an iron block on tumorigenesis in B6C3F1 mice were examined. Six-week-old female animas were divided into 4 groups and exposes to 252 Cf neutron irradiation at dose rates of 0.05 cGy/min, with (Group 1) or without (Group 2) filtering through a 10 cm thick iron block, 0.8 cGy/min (Group 3) or 0 (Group 4 controls). Total neutron exposure was 50 cGy in each of groups 1-3 and total irradiation dose was 56, 75 and 75 cGy in Groups 1-3, respectively. Total tumor incidences or multiplicity were significantly higher in Group 3 than in Group 1. A similar tendency was observed as compared to Group 2, ovarian and Harderian gland tumors being mainly affected and adrenal tumors were significantly higher in Group 2 than in Group 1. The results indicated a clear increase in tumorigenesis with the higher dose rate and no filtering influence of iron was evident, despite the drop in neutron energy level.
关键词：Fission neutron; Low dose rate; Lowering energy; Tumorigenesis; Mice