文章基本信息

标题：Effects of Irradiation on Marrow Stromal Cells with Respect to Committed Granulocyte-Macrophage Progenitor Cells.
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作者：ISAO TSUBOI ; KOHJI MORIMOTO ; ATSUSHI SAKUMA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1991
卷号：32
期号：4
页码：395-403
DOI：10.1269/jrr.32.395
摘要：The effects of irradiation on the growth regulatory function of marrow stromal cells (MSC), and on the committed granulocyte-macrophage progenitor cells (GM-CFC), were investigated using a liquid culture system. CSF activity in the supernatant of irradiated MSC (0-900 rads) increased markedly with the increase of MSC irradiation dose. CSF-inhibitory activity in the supernatant of irradiated MSC (0-900 rads) also increased with the increase of MSC irradiation dose. Furthermore, the activity of exogenous CSF added to the supernatant of 900 rad-irradiated MSC was lost more slowly than that of non-irradiated MSC. These data suggest that irradiation affected CSF production, inhibitor production and consumption of CSF by MSC.
关键词：Marrow stromal cells;Radiation;G ran ulo-macrophage progenitor cells;Colony stimulating factor