文章基本信息

标题：Post-dauer Life Span of Caenorhabditis Elegans Dauer Larvae Can be Modified by X-irradiation
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作者：Akira ONODERA ; Sumino YANASE ; Takamasa ISHII 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2010
卷号：51
期号：1
页码：67-71
DOI：10.1269/jrr.09093
摘要：The time spent as a dauer larva does not affect adult life span in Caenorhabditis elegans , as if aging is suspended in this quiescent developmental stage. We now report that modest doses X-irradiation of dauer larvae increased their post-dauer longevity. Post-irradiation incubation of young dauer larvae did not modify this beneficial effect of radiation. Conversely, holding dauer larvae prior to irradiation rendered them refractory to this X-radiation-induced response. We present a model to explain these results. These experiments demonstrate that dauer larvae provide an excellent opportunity to study mechanisms by which X irradiation can extend life span.
关键词：Aging; C;elegans ; Dauer larvae; Radiation; Beneficial effect