文章基本信息

标题：The Role of Mitochondrial Superoxide Anion (O2-) on Physiological Aging in C57BL/6J Mice
其他标题：The Role of Mitochondrial Superoxide Anion (O2-) on Physiological Aging in C57BL/6J Mice
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作者：Masaki MIYAZAWA ; Takamasa ISHII ; Kayo YASUDA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2009
卷号：50
期号：1
页码：73-83
DOI：10.1269/jrr.08097
摘要：Much attention has been focused on the mitochondrial superoxide anion (O 2 - ), which is also a critical free radial produced by ionizing radiation. The specific role of the mitochondrial O 2 - on physiological aging in mammals is still unclear despite wide-spread evidence that oxidative stress is involved in aging and age-related diseases. The major endogenous source of O 2 - is generated as a byproduct of energy metabolism from mitochondria. In order to better understand how O 2 - relates to metazoan aging, we have comprehensively examined age-related changes in the levels of oxidative damage, mitochondrial O 2 - production, mitochondrial antioxidant enzyme activity and apoptosis induction in key organs of an inbred mouse strain (C57BL/6J). Oxidative damage accumulated and excess apoptosis occurred in the brain, oculus and kidney with aging, but comparatively little occurred in the heart and muscle. These rates are correlated with O 2 - levels. Mitochondrial O 2 - production levels increased with aging in the brain, oculus and kidney, and did not significantly increased in the heart and muscle. In contrast to O 2 - production, mitochondrial SOD activities increased in heart and muscle, and remained unchanged in the brain, oculus and kidney with aging. These results suggest that O 2 - production has high organ specificity, and oxidative damage by O 2 - from mitochondria mediated apoptosis can lead to organ atrophy and physiological dysfunction. In addition, O 2 - from mitochondria plays a core role in physiological aging.
关键词：Mitochondrial superoxide anion (O 2;); Mitochondrial SOD; Oxidative damage; Apoptosis; Physiological aging