文章基本信息

标题：Fullerenol C60(OH)24 Effects on Antioxidative Enzymes Activity in Irradiated Human Erythroleukemia Cell Line
其他标题：Fullerenol C60(OH)24 Effects on Antioxidative Enzymes Activity in Irradiated Human Erythroleukemia Cell Line
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作者：Višnja BOGDANOVIĆ ; Karmen STANKOV ; Ivana IČEVIĆ 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2008
卷号：49
期号：3
页码：321-327
DOI：10.1269/jrr.07092
摘要：Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo . Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pre-treatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismutase and glutathione peroxidase in irradiated K562 cells.
关键词：Fullerenol; Radioprotection; Oxidative stress; K562 cell line