文章基本信息

标题：Locomotion-Learning Behavior Relationship in Caenorhabditis elegans Following γ-Ray Irradiation
其他标题：Locomotion-Learning Behavior Relationship in Caenorhabditis elegans Following γ-Ray Irradiation
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作者：Tetsuya SAKASHITA ; Nobuyuki HAMADA ; Daisuke D. IKEDA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2008
卷号：49
期号：3
页码：285-291
DOI：10.1269/jrr.07102
摘要：Learning impairment following ionizing radiation (IR) exposure is an important potential risk in manned space missions. We previously reported the modulatory effects of IR on salt chemotaxis learning in Caenorhabditis elegans . However, little is known about the effects of IR on the functional relationship in the nervous system. In the present study, we investigated the effects of γ-ray exposure on the relationship between locomotion and salt chemotaxis learning behavior. We found that effects of pre-learning irradiation on locomotion were significantly correlated with the salt chemotaxis learning performance, whereas locomotion was not directly related to chemotaxis to NaCl. On the other hand, locomotion was positively correlated with salt chemotaxis of animals which were irradiated during learning, and the correlation disappeared with increasing doses. These results suggest an indirect relationship between locomotion and salt chemotaxis learning in C. elegans , and that IR inhibits the innate relationship between locomotion and chemotaxis, which is related to salt chemotaxis learning conditioning of C. elegans .
关键词：Nematode; Learning; Nervous system; Ionizing Radiation