文章基本信息

标题：A Model for the Induction of DNA Damages by Fast Neutrons and their Evolution into Cell Clonogenic Inactivation
其他标题：A Model for the Induction of DNA Damages by Fast Neutrons and their Evolution into Cell Clonogenic Inactivation
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作者：Hiroshi YAMAGUCHI ; Anthony J. WAKER
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2007
卷号：48
期号：4
页码：289-303
DOI：10.1269/jrr.06107
摘要：It has been long stated that cellular inactivation through neutron irradiation is mainly caused by energy deposition in DNA molecules from recoiled secondary charged particles. Complexities associated with neutrons, such as the generally broad energy spectrum and the inherently wide energy spectrum of the induced charged particles, not to mention that the dependence of cellular inactivation by charged particles on radiation quality is yet to be fully understood, make it difficult to check this statement. Recently a molecular model has been proposed that improves the quantitative explanation of the dependence of cellular inactivation by charged particles on radiation quality. An attempt was made to apply this model for analysis of neutron cellular inactivation. As a preliminary result it is suggested that neutron cellular inactivation is caused not only by secondary charged particles but also by an "atomic deletion" effect, generated by a stripped atom recoiling from a DNA molecule. This effect seems to be of significant importance, the inactivation cross section of this effect for fission neutrons is as much as 15% (aerobic conditions) or 55% (hypoxic) of the total, and the severity of one occurrence of atomic deletion by a single neutron is estimated as much as 3.1 ± 1.1 times (aerobic) or 6.8 ± 1.2 times (hypoxic) higher than the severity of one event by a single track of a charged particle interacting with DNA.
关键词：Model; Radiation mechanism; Inactivation cross section; DNA damage; Neutron