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标题：Radioprotective Property of the Ethanolic Extract of Piper betel Leaf
其他标题：Radioprotective Property of the Ethanolic Extract of Piper betel Leaf
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作者：Sayanti BHATTACHARYA ; Mahesh SUBRAMANIAN ; Susri ROYCHOWDHURY 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2005
卷号：46
期号：2
页码：165-171
DOI：10.1269/jrr.46.165
摘要：The radioprotective activity of Piper betel ethanolic extract (PE) has been studied using rat liver mitochondria and pBR 322 plasmid DNA as two model in vitro systems. The extract effectively prevented γ-ray induced lipid peroxidation as assessed by measuring thiobarbituric acid reactive substrates, lipid hydroperoxide and conjugated diene. Likewise, it prevented radiation-induced DNA strand breaks in a concentration dependent manner. The radioprotective activity of PE could be attributed to its hydroxyl and superoxide radicals scavenging property along with its lymphoproliferative activity. The radical scavenging capacity of PE was primarily due to its constituent phenolics, which were isolated and identified as chevibetol and allyl pyrocatechol.
关键词：Lymphoproliferation; Piper betel ; Radioprotection; ROS scavenging; Lipids; DNA