文章基本信息

标题：Preferential Sensitization of Tumor Cells to Radiation by Heat Shock Protein 90 Inhibitor Geldanamycin
其他标题：Preferential Sensitization of Tumor Cells to Radiation by Heat Shock Protein 90 Inhibitor Geldanamycin
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作者：Yoshitaka MATSUMOTO ; Hikaru MACHIDA ; Nobuo KUBOTA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2005
卷号：46
期号：2
页码：215-221
DOI：10.1269/jrr.46.215
摘要：The purpose of this study was to investigate the radiosensitizing effect of geldanamycin (GA), an inhibitor of heat shock protein 90, on tumour cells and normal cells. We tested the effect of a combination of GA and radiation on cell survival, PI3K/Akt-related proteins and apoptosis induction. GA sensitized tumour cells to radiation in preference to normal cells. In addition, a combination of radiation and GA abolished Akt activities and strongly enhanced the induction of apoptosis in tumour cells which depend on Akt protein activities for cell survival. The present data support the hypothesis that GA sensitizes tumour cells by modulating the balance among mitogenic, antiproliferative and apoptotic pathways. Targeting Hsp90 in tumour cells may lead to the development of new radiosensitizing strategies in radiotherapy.
关键词：Hsp90; Geldanamycin; Radiosensitization; Akt; Tumour cells; Normal cells