文章基本信息

标题：Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs
其他标题：Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs
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作者：Tomoyuki HAMAMOTO ; Keiji SUZUKI ; Hitoshi SASAKI 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2005
卷号：46
期号：2
页码：197-203
DOI：10.1269/jrr.46.197
摘要：Methods to predict the responsiveness of a particular tumor to a particular anticancer drug are desirable not only for chemotherapy but also for chemoradiotherapy. Here, we examined the effects of viral or activated oncogenes on sensitivity to anticancer drugs by using SHOK (Syrian hamster Osaka-Kanazawa) cells and their transfectants. The IC 50 of each transfectant was compared with that of the pSV2Neo transfected control. Cells transfected with the c- myc , v- mos , or v- fgr gene increased their sensitivity to bleomycin, while those transfected with the H- ras gene developed resistance. Resistance to cisplatin was conferred by the introduction of the H- ras or c- cot gene. In the case of adriamycin, the c- myc or c- cot transfectant increased sensitivity and the H- ras transfectant decreased it. Mitomycin C resistance was observed by the introduction of the K- ras gene. Thus, the H- ras gene was found to be involved in the development of resistance to three of the four anticancer drugs. In addition, we have for the first time shown that mos and cot have an effect on sensitivity to three and all of the four anticancer drugs, respectively. These results suggest that the expression of each oncogene would differently affect sensitivity to the four anticancer drugs used in this study, and this property could be a possible marker to predict chemosensitivity.
关键词：Oncogene; SHOK cells; Chemosensitivity; IC 50