文章基本信息

标题：Changes in the Pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation: Comparison with γ-Ray Radiation
其他标题：Changes in the Pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation: Comparison with γ-Ray Radiation
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作者：Takayuki OBATA ; Koichi ANDO ; Sachiko KOIKE 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2004
卷号：45
期号：2
页码：261-267
DOI：10.1269/jrr.45.261
摘要：We performed dynamic MRI to reveal the characteristic gadopentetate dimeglumine (Gd-DTPA) uptake in carbon-ion irradiated tumor and compare it with photon irradiation. Fibrosarcomas in C3H mice legs were irradiated with either 16 Gy of carbon ions (74 keV/mm) or an equivalent dose (30 Gy) of Cs-137 γ-rays. Dynamic MRI was performed 1 or 6 days after irradiation when the tumors showed an initial growth delay or incipient regrowth, respectively. The enhancement pattern was visualized by mapping the maximum enhanced time ( Tmax ), relative signal intensity maximum ( SImax ), and time delay of starting enhancement ( Td ). Significantly larger Tmax and Td values were observed in the tumors 1 day after carbon-ion irradiation than in the nonradiated tumors ( No-R ) and tumors 1 day after γ-ray irradiation. Among the selected pixels in the tumors 6 days after carbon irradiation, 77% had Tmax values of less than 120 sec, significantly more than in the No-R group. The Tmax maps for the tumors irradiated with γ-rays showed a similar tendency to the carbon-irradiated ones, and only a significant difference was obtained between tumors 1 and 6 days after irradiation. Tmax and Td in the carbon-ion irradiated tumors were different from those in the γ-ray-irradiated tumors. These treatment-specific kinetics may be useful in predicting the therapeutic efficacy of carbon-ion treatment.
关键词：Pharmacokinetics; Charged particle radiation; Tumor; Gd-DTPA enhanced MR imaging