文章基本信息

标题：Chromosomal Aberrations in Lymphocytes of Lung Cancer Patients Treated with Carbon Ions
其他标题：Chromosomal Aberrations in Lymphocytes of Lung Cancer Patients Treated with Carbon Ions
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作者：Ryonfa LEE ; Shigeru YAMADA ; Naoyoshi YAMAMOTO 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2004
卷号：45
期号：2
页码：195-199
DOI：10.1269/jrr.45.195
摘要：The purpose of this study is to investigate the normal tissue damage caused by carbon-ion therapy. We measured chromosomal aberrations in peripheral blood lymphocytes before, during, and after radiotherapy, using the techniques of fluorescence in situ hybridization (FISH) and chemically induced premature chromosome condensation (PCC). Twenty-two lung cancer patients treated at HIMAC (Heavy Ion Medical Accelerator in Chiba) entered the study and signed an informed consent. Frequencies of lymphocytes with chromosomal aberrations at the end of carbon-ion therapy varied among the patients. This frequency was significantly correlated to the radiation field size and weakly correlated to the counts of white blood cells and lymphocytes during the treatment. As a result, we have found that chromosomal aberrations in peripheral blood lymphocytes from patients treated for lung cancer by carbon-ions were dependent on target volume, possibly reflecting the increased involvement of lymph nodes in the target field.
关键词：Chromosomal aberrations; Heavy ions; Radiation therapy; Lung cancer; Human lymphocytes