文章基本信息

标题：Induction of Chromatin Damage and Distribution of Isochromatid Breaks in Human Fibroblast Cells Exposed to Heavy Ions
其他标题：Induction of Chromatin Damage and Distribution of Isochromatid Breaks in Human Fibroblast Cells Exposed to Heavy Ions
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作者：TETSUYA KAWATA ; HISAO ITO ; KEN MOTOORI 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2002
卷号：43
期号：S
页码：169-173
DOI：10.1269/jrr.43.S169
摘要：The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to γ-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.
关键词：High-LET radiation; Premature chromosome condensation; Isochromatid break; Calyculin A