文章基本信息

标题：New Strategies for the Prevention of Radiation Injury: Possible Implications for Countering Radiation Hazards of Long-term Space Travel
其他标题：New Strategies for the Prevention of Radiation Injury: Possible Implications for Countering Radiation Hazards of Long-term Space Travel
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作者：THOMAS SEED ; SREE KUMAR ; MARK WHITNALL 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2002
卷号：43
期号：S
页码：239-244
DOI：10.1269/jrr.43.S239
摘要：New strategies for the prevention of radiation injuries are currently being explored with the ultimate aim of developing globally radioprotective, nontoxic pharmacologics. The prophylactic treatments under review encompass such diverse pharmacologic classes as novel immunomodulators, nutritional antioxidants, and cytokines. An immunomodulator that shows promise is 5-androstenediol (AED), a well-tolerated, long-acting androstene steroid with broad-spectrum radioprotective attributes that include not only protection against acute tissue injury, but also reduced susceptibility to infectious agents, as well as reduced rates of neoplastic transformation. Other potentially useful radioprotectants currently under study include the nutraceutical vitamin E and analogs, a chemically-engineered cytokine, interleukin-1β, and a sustained-release formulation of an aminothiol, amifostine. Results suggest that a new paradigm is evolving for the prophylaxes of radiation injuries, based on use of newly identified, nontoxic, broad-spectrum prophylactic agents whose protective action may be leveraged by subsequent postexposure use of cytokines with organ-specific reparative functions.
关键词：Radiation injury; Radioprotectors; Space travel; Prophylaxis; Therapy