文章基本信息

标题：Tumorigenesis in Infant C3H/HeN Mice Exposed to Tritiated Water (HTO)
其他标题：Tumorigenesis in Infant C3H/HeN Mice Exposed to Tritiated Water (HTO)
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作者：HONG YIN ; DILIP BHATTACHARJEE ; GOUTUM ROY 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2002
卷号：43
期号：4
页码：345-351
DOI：10.1269/jrr.43.345
摘要：The purpose of this study was to determine the carcinogenicity and retention of tritiated water (HTO) in mice. A two-part study was undertaken. In an HTO-incorporation study, both sexes of 12-day old C3H/HeN mice were i.p. injected with 3.70 MBq/pup of HTO and sacrificed 3 hr and 1, 3, 7, 14 days after HTO administration; in a carcinogenicity study, pups were given a single i.p. injection of HTO at doses of 0, 0.23, 0.92 and 3.70 MBq/mouse, and then observed for 14 months. The survival rates of both sexes slightly decreased upon increasing the HTO administered doses. The results indicated that the administration of HTO to infants led to a significant increase of liver tumors in male mice, but not in females. In female mice, ovarian tumors were observed for the high-dose group of injected HTO.
关键词：Tritiated water;Retention;Tumorigenesis;Sex difference;C3H/HeN mice